seal oil, omega3, antioxidant antiaging

Johansen O, Seljeflot I, Hostmark AT, Arnesen H. The Effect of Supplementation WithOmega-3 Fatty Acids on Soluble Markers of Endothelial Function in Patients withCoronary Heart Disease. Arteriosclerosis Thombosis Vascular Biolology 1999. July 19(7): 1681-6.

Conclusions: Results of study on 54 patients with coronary heart disease, including control group, indicate that Omega-3 fatty acids supplementation decreases hemostatic markers of atherosclerosis, whereas markers of inflammation may be increased. The latter may be the result of lipid peroxidation as a simultaneous decrease of vitamin E and increase in thiobarbituric acid-reactive substances were observed.

-----------------------------------------------------------------------------------

Kanayasu-Toyoda et al., Prostaglandins, Leukotrienes and Essential Fatty Acids 54:319-325, 1996.

Conclusions: DPA which accumulates in phospholipids is known to act as a potent stimulator of endothelial cell (EC) migration. EC migration plays an important role in wound repaid of blood vessels. Direct pre-treatment of ECs with DPA is known to result in a dose-dependent increase in migration in response to fetal bovine serum, suggesting that DPA is a powerful anti-atherogenic agent with up to 10 times more activity than that of EPA in stimulating the migration of endothelial cells.

-----------------------------------------------------------------------------------------

Leaf A. The Role of Omega 3 Fatty Acids in the Prevention and Rehabilitation of Coronary Artery Disease. Ann Acad Med Singapore 1992 January; 21 (1);132-6.

Conclusions: Dietary modifications, including fish oil supplements, have been strongly advocated to prevent the development of atherosclerosis. The pathophysiological basis of the evidence for recommending fish and fish oil supplementation in the prevention of atherosclerosis is reviewed.

-------------------------------------------------------------------------------------

Meydani M. Omega-3 Fatty Acids Alter Soluble Markers of Endothelial Function inCoronary Heart Disease Patients. Nutritional Review, February 2000 58 (2 Pt 1):56-9.

Conclusions: Supplementation of patients with fish oil following coronary angioplasty showed decreases in several plasma markers of endothelial hemostatic activity indicating a healthier and better vasculature associated with fish oil supplementation.

-----------------------------------------------------------------------------------------

Seidelin KN, Myrup B, Fischer-Hansen B, Omega-3 Fatty Acids in Adipose Tissue andCoronary Artery Disease are Inversely Related, American Journal of Clinical Nutrition1992 June; 55(6): 1117-9.

Conclusions: The study investigated the possible beneficial effect of fish consumption on coronary atherosclerosis, and found support for the hypothesis that fish consumption is associated with a reduced risk of coronary heart disease.

------------------------------------------------------------------------------------------

Toshie Kanayasu-Toyoda, Ikuo Morita, Sei-itsu Murota, Docosapentaenoic Acid (22:5,n-3), an Elongation Metabolite of Eicosapentaenoic Acid (20:5, n-3), is A Potent Stimulator of Endothelial Cell Migration on Pretreatment in Vitro. Pearson Professional Ltd. 1995.

Conclusions: Endothelial cell (EC) migration plays an important role in wound repair of blood vessels. DPA is a potent stimulator of EC migration. Lipid analysis demonstrated that direct DPA pre-treatment sufficiently increased the absolute quantity of phospholipids of ECs. Cycloxygenase inhibitor and lipoxgenase inhibitor did not abolish the stimulative effect of DPA pre-treatment on EC migration. DPA pre-treatment had no effect on smooth muscle cell migration. These data suggest that the stimulative effect of EPA on EC migration occurs via DPA, and that DPA may act as a powerful anti- atherogenic factor.

-----------------------------------------------------------------------------------------

ARTHRITIS

Kremer JM, Clinical Studies of Omega-3 Fatty Acid Supplementation in Patients Who Have Rheumatoid Arthritis. Rheum Dis Clin North Am 1991 May 17(2); 391-402.

Conclusions: Several studies have demonstrated reproducible clinical benefits of rheumatoid arthritis disease activity after ingestion of Omega-3 fatty acids, including: decreases in the production of leukotriene B4, platelet activating factor and interleukin-1.

-----------------------------------------------------------------------------------